From the A1 motorway take the exit Firenze Sud and stay on the ringroad until the last traffic light.
Turn left and continue along the Viali di Circonvallazione until you reach Piazza della Libertà, and then follow the signs to the railway station of Santa Maria Novella.
At the end of Via Nazionale, keep on your left, pass the traffic lights and enter Piazza dell'Unità; take Via del Melarancio, cross the little square, and take Via Cerretani. The hotel is located on the right.